What role do T cells play during respiratory syncytial virus infection?
A ROLE FOR THE TH- 17 ANSWER IN LUNG DESEASE INCREASED BY RSV.
Respiratory syncytial virus (RSV) is the leading viral cause of hospitalization for respiratory disease in infants and children worldwide with clinical manifestations such as bronchiolitis and / or pneumonia. Over 95% of the children have been infected by the virus after its second winter season.
In 1966 a formalin-inactivated vaccine (FIRSV) against RSV was administered to children in the U.S. . In the winter of 1967 immunized children exposed to the virus got an increment in the frequency and severity of lower respiratory tract disease and there was a higher incidence of hospitalization.
Two of the immunized children died due to the infection. Even today, more than 50 years of FIRSV vaccine administration, the severity caused by it, is still associated with an immune response deviation to T-helper type 2 (Th-2).
A new sub-set of T cells called T-helper type 17 (TH-17) have been characterized by the secretion of interleukin 17 (IL-17), which is important for the recruitment of neutrophils. It has been demonstrated that the response Th-17 can be important in the defense against many microorganisms (including viruses), despite the fact that it can also contribute to immunopathology.
Preliminary data from our laboratory suggest that Th-17 response would play a key role in Augmented Pulmonary Disease (APD).
The objective of this research is to determine the role of Th-17 lymphocytes in the APD caused by RSV in children immunized with FIRSV vaccine.
INFANT and Vanderbilt University